Many experiments in the life sciences require well controlled and reliable application of pressure. For example in neuroscience research, steps ranging from (virus) injections into the intact brain, over puff application of compounds, to patch clamping recording all require a controlled source of pressure. In the past, applying pressure with your mouth was seen as the most sensitive and best controlled approach, and many researchers still do this. More widespread, in particular where higher pressures are required is the use of syringes to apply pressure manually through a syringe. Even with manometer readout, both of these approaches yield unreproducible results, as stability of pressure application, exact timing and actual pressure levels will vary substantially.